A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

DPA37

tert-Butyloxycarbonyl-Valine-α,β‐dehydrophenylalanine-α,β‐dehydrophenylalanine-Valine-α,β‐dehydrophenylalanine-α,β‐dehydrophenylalanine-Valine-Methyl ester

Sequence: Boc-V-ΔF-ΔF-V-ΔF-ΔF-V-OMe

Core Sequence: V-ΔF-ΔF-V-ΔF-ΔF

R Value: 0.048

Residue Involved: Valine | α,β‐dehydrophenylalanine | α,β‐dehydrophenylalanine | Valine | α,β‐dehydrophenylalanine | α,β‐dehydrophenylalanine

Conformation: Right-handed 3(10) helical

Reference

Mitra, S., Dey, S., Karthikeyan, S. and Singh, T. (1997). Design of specific structures using α, β-dehydro-phenylalanine residues: Synthesis, crystal structure, and molecular conformation of Boc-L-Val-ΔPhe-ΔPhe-L-Val-ΔPhe-ΔPhe-L-Val-OCH3, a 310-helical heptapeptide. Biopolymers, 41(1), pp.97-105.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Valine-α,β‐dehydrophenylalanine-α,β‐dehydrophenylalanine-Valine-α,β‐dehydrophenylalanine-α,β‐dehydrophenylalanine-Valine-Methyl ester
Sequence: Boc-V-ΔF-ΔF-V-ΔF-ΔF-V-OMe
Core Sequence: V-ΔF-ΔF-V-ΔF-ΔF
Sequence Length: 6
Molecular Weight (amu): 1042.244
Molecular Formula: C57-H67-N7O10-C-H3-O-H
R Value: 0.048
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: Right-handed 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Valine -59.8 -28.2 174.0
α,β‐dehydrophenylalanine -54.6 -18.7 165.5
α,β‐dehydrophenylalanine -52.2 -17.5 175.6
Valine -61.0 -17.0 172.6
α,β‐dehydrophenylalanine -61.5 -7.9 160.8
α,β‐dehydrophenylalanine -49.7 -30.9 175.9