A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB47

tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-Aib-A-L-Aib-A-L-Aib-A-L-Aib-OMe

Core Sequence: Aib-A-L-Aib-A-L-Aib-A-L-Aib

R Value: 0.075

Residue Involved: Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid

Conformation: 3(10) helical

Reference

Karle, I., Flippen-Anderson, J., Uma, K. and Balaram, P. (1988). Aqueous channels within apolar peptide aggregates: solvated helix of the alpha-aminoisobutyric acid (Aib)-containing peptide Boc-(Aib-Ala-Leu)3-Aib-OMe.2H2O.CH3OH in crystals. Proceedings of the National Academy of Sciences, 85(2), pp.299-303.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-Aib-A-L-Aib-A-L-Aib-A-L-Aib-OMe
Core Sequence: Aib-A-L-Aib-A-L-Aib-A-L-Aib
Sequence Length: 10
Molecular Weight (amu): 1025.3 ± 68.1
Molecular Formula: C49H88-N10-O13. 2H2O-CH3OH
R Value: 0.075
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Alpha amino iso butyric acid -54 -40.3 -176
Alanine -62.8 -23.4 179.8
Leucine -101.8 15.2 -178.3
Alpha amino iso butyric acid -49.5 -45.6 -172.6
Alanine -69.9 -29.7 174.9
Leucine -64.3 -49.3 178.7
Alpha amino iso butyric acid -55.1 -41.5 -176.4
Alanine -65.9 -42.9 -171
Leucine -90.2 -37.5 -178.5
Alpha amino iso butyric acid 53 -145.6 -175.5