A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB41

tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Alanine-Leucine-Alanine-Alpha amino iso butyric acid-Amino-iso-butyric-Leucine-Alanine-Leucine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-Aib-A-L-A-Aib-Aib-L-A-L-Aib-OMe

Core Sequence: Aib-A-L-A-Aib-Aib-L-A-L-Aib

R Value: 0.074

Residue Involved: Alpha amino iso butyric acid | Alanine| Leucine| Alanine| Alpha amino iso butyric acid | Alpha amino iso butyric acid | Leucine| Alanine| Leucine| Alpha amino iso butyric acid

Conformation: Alpha helical

Reference

Karle, I., Flippen-Anderson, J., Uma, K., Sukumar, M. and Balaram, P. (1990). Modular design of synthetic protein mimics. Crystal structures, assembly, and hydration of two 15- and 16-residue apolar, leucyl-rich helical peptides. Journal of the American Chemical Society, 112(25), pp.9350-9356.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Alanine-Leucine-Alanine-Alpha amino iso butyric acid-Amino-iso-butyric-Leucine-Alanine-Leucine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-Aib-A-L-A-Aib-Aib-L-A-L-Aib-OMe
Core Sequence: Aib-A-L-A-Aib-Aib-L-A-L-Aib
Sequence Length: 10
Molecular Weight (amu): 1025.2+60.1*
Molecular Formula: C49-H88-N10-O13-C3-H7-OH
R Value: 0.074
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: Alpha helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Alpha amino iso butyric acid -57 -56 -170
Alanine -66 -34 180
Leucine -69 -42 177
Alanine -63 -43 180
Alpha amino iso butyric acid -53 -51 -174
Alpha amino iso butyric acid -58 -50 -170
Leucine -77 -29 177
Alanine -71 -34 180
Leucine -80 -23 -169
Alpha amino iso butyric acid 51 46 178