A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB35

tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Leucine-Alpha amino iso butyric acid-Amino-iso-butyric-Leucine-Leucine-Leucine-Alpha amino iso butyric acid-Leucine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-Aib-L-Aib-Aib-L-L-L-Aib-L-Aib-OMe

Core Sequence: Aib-L-Aib-Aib-L-L-L-Aib-L-Aib

R Value: 0.107

Residue Involved: Alpha amino iso butyric acid | Leucine| Alpha amino iso butyric acid | Alpha amino iso butyric acid | Leucine| Leucine| Leucine| Alpha amino iso butyric acid | Leucine| Alpha amino iso butyric acid

Conformation: Helical

Reference

Karle, I., Flippen-Anderson, J., Sukumar, M. and Balaram, P. (1992). Helix packing of leucine-rich peptides: A parallel leucine ladder in the structure of Boc-Aib-Leu-Aib-Aib-Leu-Leu-Leu-Aib-Leu-Aib-OMe. Proteins: Structure, Function, and Genetics, 12(4), pp.324-330.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Leucine-Alpha amino iso butyric acid-Amino-iso-butyric-Leucine-Leucine-Leucine-Alpha amino iso butyric acid-Leucine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-Aib-L-Aib-Aib-L-L-L-Aib-L-Aib-OMe
Core Sequence: Aib-L-Aib-Aib-L-L-L-Aib-L-Aib
Sequence Length: 10
Molecular Weight (amu): 1123
Molecular Formula: C56-H102-N10-O13
R Value: 0.107
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: Helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Alpha amino iso butyric acid -63 -60 -172
Leucine -68 -52 180
Alpha amino iso butyric acid -47 -54 -171
Alpha amino iso butyric acid -60 -51 -168
Leucine -79 -29 175
Leucine -70 -46 176
Leucine -58 -36 177
Alpha amino iso butyric acid -55 -33 -179
Leucine -67 -33 175
Alpha amino iso butyric acid 47 54 175