A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB30

tert-Butyloxycarbonyl-Dehydro Phenylalanine-Alpha amino iso butyric acid-Amino-iso-butyric-Alpha amino iso butyric acid-Amino-iso-butyric-Glycine-Leucine-Alpha amino iso butyric acid-Amino-iso-butyric-Methyl ester

Sequence: Boc-ΔF-Aib-Aib-Aib-Aib-G-L-Aib-Aib-OMe

Core Sequence: ΔF-Aib-Aib-Aib-Aib-G-L-Aib-Aib

R Value: 0.0595

Residue Involved: Dehydro-Phenylalanine| Alpha amino iso butyric acid | Alpha amino iso butyric acid | Alpha amino iso butyric acid | Alpha amino iso butyric acid | Glycine| Leucine| Alpha amino iso butyric acid | Alpha amino iso butyric acid

Conformation: 3(10) helical

Reference

Karle, I., Flippen-Anderson, J., Uma, K. and Balaram, P. (1993). Accommodation of aD-Phe residue into a right-handed 310-helix: Structure of Boc-D-Phe-(Aib)4-Gly-L-Leu-(Aib)2-Ome, an analogue of the amino terminal segment of antiamoebins and emerimicins. Biopolymers, 33(3), pp.401-407.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Dehydro Phenylalanine-Alpha amino iso butyric acid-Amino-iso-butyric-Alpha amino iso butyric acid-Amino-iso-butyric-Glycine-Leucine-Alpha amino iso butyric acid-Amino-iso-butyric-Methyl ester
Sequence: Boc-ΔF-Aib-Aib-Aib-Aib-G-L-Aib-Aib-OMe
Core Sequence: ΔF-Aib-Aib-Aib-Aib-G-L-Aib-Aib
Sequence Length: 9
Molecular Weight (amu): 958
Molecular Formula: C47-H75-N9-O12
R Value: 0.0595
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Dehydro-Phenylalanine -64 -32 -178
Alpha amino iso butyric acid -54 -27 -179
Alpha amino iso butyric acid -53 -32 -177
Alpha amino iso butyric acid -51 -43 -175
Alpha amino iso butyric acid -57 -28 -179
Glycine -63 -21 176
Leucine -72 -30 175
Alpha amino iso butyric acid -62 -43 -170
Alpha amino iso butyric acid 52 43 176f