A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB28

tert-Butyloxycarbonyl-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-L-Aib-A-L-Aib-A-F-Aib-OMe

Core Sequence: L-Aib-A-L-Aib-A-F-Aib

R Value: 0.073

Residue Involved: Leucine| Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid | Alanine| Phenylalanine| Alpha amino iso butyric acid

Conformation: 3(10) helical

Reference

Karle, I., Flippen-Anderson, J., Gurunath, R. and Balaram, P. (1994). Facile transition between 310- and α-helix: Structures of 8-, 9-, and 10-residue peptides containing the -(Leu-Aib-Ala)2-Phe-Aib-fragment. Protein Science, 3(9), pp.1547-1555.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-L-Aib-A-L-Aib-A-F-Aib-OMe
Core Sequence: L-Aib-A-L-Aib-A-F-Aib
Sequence Length: 8
Molecular Weight (amu): 1174.46 + 18.02
Molecular Formula: C60-H91-N11-O13-H2-0
R Value: 0.073
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Leucine -54 -37 -179
Alpha amino iso butyric acid -50 -32 -177
Alanine -60 -23 176
Leucine -69 -13 -171
Alpha amino iso butyric acid -51 -31 -179
Alanine -61 -22 -176
Phenylalanine -96 10 -178
Alpha amino iso butyric acid -49 139