A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB27

tert-Butyloxycarbonyl-Tryptophan-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-W-L-Aib-A-L-Aib-A-F-Aib-OMe

Core Sequence: W-L-Aib-A-L-Aib-A-F-Aib

R Value: 0.054

Residue Involved: Tryptophan| Leucine| Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid | Alanine| Phenylalanine| Alpha amino iso butyric acid

Conformation: 3(10) helical

Reference

Karle, I., Flippen-Anderson, J., Gurunath, R. and Balaram, P. (1994). Facile transition between 310- and α-helix: Structures of 8-, 9-, and 10-residue peptides containing the -(Leu-Aib-Ala)2-Phe-Aib-fragment. Protein Science, 3(9), pp.1547-1555.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Tryptophan-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-W-L-Aib-A-L-Aib-A-F-Aib-OMe
Core Sequence: W-L-Aib-A-L-Aib-A-F-Aib
Sequence Length: 9
Molecular Weight (amu): 1089.36
Molecular Formula: C56-H84-N10-O12
R Value: 0.054
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Tryptophan -62 -31 -178
Leucine -58 -27 179
Alpha amino iso butyric acid -54 -33 -176
Alanine -67 -20 176
Leucine -63 -19 177
Alpha amino iso butyric acid -51 -32 174
Alanine -67 -25 -173
Phenylalanine -150 5 Unmeasured
Alpha amino iso butyric acid -50 137 Unmeasured