A manually curated database of peptides containing Dehydro-Phenyl-Alanine and Amino-Iso-Butyric Acid
Protein Data Bank[PDB] Structured Data File [SDF]

AIB26

tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Tryptophan-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester

Sequence: Boc-Aib-W-L-Aib-A-L-Aib-A-F-Aib-OMe

Core Sequence: Aib-W-L-Aib-A-L-Aib-A-F-Aib

R Value: 0.083

Residue Involved: Alpha amino iso butyric acid | Tryptophan| Leucine| Alpha amino iso butyric acid | Alanine| Leucine| Alpha amino iso butyric acid | Alanine| Phenylalanine| Alpha amino iso butyric acid

Conformation: 3(10) helical

Reference

Karle, I., Flippen-Anderson, J., Gurunath, R. and Balaram, P. (1994). Facile transition between 310- and α-helix: Structures of 8-, 9-, and 10-residue peptides containing the -(Leu-Aib-Ala)2-Phe-Aib-fragment. Protein Science, 3(9), pp.1547-1555.

Chemical Component Summary

Name of Peptide: tert-Butyloxycarbonyl-Alpha amino iso butyric acid-Tryptophan-Leucine-Alpha amino iso butyric acid-Alanine-Leucine-Alpha amino iso butyric acid-Alanine-Phenylalanine-Alpha amino iso butyric acid-Methyl ester
Sequence: Boc-Aib-W-L-Aib-A-L-Aib-A-F-Aib-OMe
Core Sequence: Aib-W-L-Aib-A-L-Aib-A-F-Aib
Sequence Length: 10
Molecular Weight (amu): 903.14 + 68.08
Molecular Formula: C45-H74-N8-O11-2H2-O-C-H3-O-H
R Value: 0.083
N-Terminal Modification: tert-Butyloxycarbonyl
C-Terminal Modification: Methyl ester
Conformation: 3(10) helical
Method: X - Ray Diffraction
Core Residue Involved Phi Psi Omega
Alpha amino iso butyric acid -63 -21 -178
Tryptophan -58 -29 180
Leucine -53 -33 -176
Alpha amino iso butyric acid -56 -45 -176
Alanine -70 -32 171
Leucine -64 -49 -178
Alpha amino iso butyric acid -55 -46 -175
Alanine -72 -24 175
Phenylalanine -77 -47 -174
Alpha amino iso butyric acid -47 -48 -176